Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

A new pharmacological role for thalidomide: Attenuation of morphine-induced tolerance in rats

(2016) A new pharmacological role for thalidomide: Attenuation of morphine-induced tolerance in rats. Acta Anaesthesiologica Taiwanica.

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Abstract

Objective Tolerance to the analgesic effect is the main side effect of chronic administration of opioids. Several drugs have been studied to try to find agents to prevent the development of this phenomenon. In the present study we aimed to evaluate the effect of thalidomide on morphine-induced tolerance to the analgesic effect. Methods Groups of male rats were randomly rendered and received daily morphine in combination with thalidomide vehicle or thalidomide (2.5 mg/kg, 5 mg/kg, or 10 mg/kg, intraperitoneally). Nociception was measured using the plantar test apparatus. Latency time was recorded when the animal reacted to the light stimulus; licking or raising its hind paw. Treatments and evaluations continued until completion of tolerance to the analgesic effect of morphine. Results Our findings indicated that tolerance was achieved following 11 days of morphine administration, while thalidomide postponed the day of tolerance completion for 4 days (2.5 mg/kg and 5 mg/kg thalidomide) or 10 days (10 mg/kg thalidomide). Moreover, thalidomide prevented the morphine-induced shift to the right of the ED50 in the dose�response curve. Conclusion It was concluded that thalidomide attenuated the morphine-induced tolerance to the analgesic effect. © 2016

Item Type: Article
Keywords: morphine sulfate; thalidomide; morphine; thalidomide, analgesic activity; animal experiment; Article; controlled study; dose response; drug dose; hind paw; latent period; licking; male; morphine tolerance; mouse; nociception; nonhuman; shift to the right; treatment duration; animal; drug tolerance; rat; Wistar rat, Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Rats; Rats, Wistar; Thalidomide
Page Range: pp. 65-69
Journal or Publication Title: Acta Anaesthesiologica Taiwanica
Volume: 54
Number: 2
Publisher: Elsevier Taiwan LLC
Identification Number: 10.1016/j.aat.2016.06.002
ISSN: 18754597
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/550

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