Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Adenosine deaminase activity in chronic lymphocytic leukemia and healthy subjects

(2016) Adenosine deaminase activity in chronic lymphocytic leukemia and healthy subjects. International Journal of Cancer Management.

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Background: B cell chronic lymphocytic leukemia is one of the most frequent hematologic malignancies in the world. Cellular surface CD markers and serum Beta-2-microglobulin may be used as a prognostic tool in CLL patients. Objectives: In the present study we introduce serum adenosine deaminase as a diagnostic marker in CLL. MaterialsandMethods: Blood sampleswere collected from B-CLL and healthy subjects. White blood cell, red blood cell and platelet count and blood Erythrocyte sedimentation rate was recorded and serum Beta-2-microglobulin, Lactate dehydrogenase and total ADA enzyme activity were determined. Results: Serum ADA activity was significantly higher in patients group than that of controls. ADA had a significant and direct correlation with B2M, WBC, LDH and ESR. However, there was not any relation between ADA and the stages of disease. Diagnostic cut-off, sensitivity and specificity of the serum ADA test were 27.97 U/L, 91 and 94, respectively. Conclusions: A higher ADA activity in patients group and its correlation with CLL markers were seen in our study. High diagnostic value of serum ADA in our study suggests that it might be considered as a useful screening tool among the other markers in CLL. © 2016, Iranian Journal of Cancer Prevention.

Item Type: Article
Keywords: adenosine deaminase; beta 2 microglobulin; cyclophosphamide; doxorubicin; fludarabine; lactate dehydrogenase; prednisolone; vincristine, adult; aged; Article; blood sampling; chronic lymphatic leukemia; clinical article; controlled study; diagnostic value; enzyme activity; enzyme blood level; erythrocyte count; erythrocyte sedimentation rate; female; human; leukocyte count; male; screening test; sensitivity and specificity; thrombocyte count
Page Range: pp. 1-6
Journal or Publication Title: International Journal of Cancer Management
Volume: 9
Number: 3
Identification Number: 10.17795/ijcp-5069
ISSN: 25384422
Depositing User: مهندس جمال محمودپور

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