Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Association of ABCB1 and ABCG2 single nucleotide polymorphisms with clinical findings and response to chemotherapy treatments in Kurdish patients with breast cancer

(2016) Association of ABCB1 and ABCG2 single nucleotide polymorphisms with clinical findings and response to chemotherapy treatments in Kurdish patients with breast cancer. Tumor Biology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The possible interaction between gene polymorphisms and risk of cancer progression is very interesting. Polymorphisms in multi-drug resistance genes have an important role in response to anti-cancer drugs. The present study was aimed to evaluate the possible effects of ABCB1 C3435T and ABCG2 C421A single nucleotide polymorphisms on clinical and pathological outcomes of Kurdish patients with breast cancer. One hundred breast cancer patients and 200 healthy controls were enrolled in this case�control study. Clinical and pathological findings of all individuals were reported, and immunohistochemistry staining was used to assess the tissue expression of specific breast cancer proteins. The ABCB1 C3435T and ABCG2 C421 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). The distribution of different genotypes between patient and control groups was only significant for ABCG2 C421A. A allele of ABCG2 C421A polymorphisms were significantly higher in patients than in controls. Patients with AA genotype of ABCG2 C421A were at higher risk of progressing breast cancer. Patients with A allele of ABCG2 had complete response to chemotherapeutic agents. There was no statistically significant association between ABCB1 C3435T and ABCG2 C421A polymorphisms and tissue expression of ER, PR, Her2/neu, and Ki67. The ABCB1 C3435T has no correlation with clinical findings and treatment with chemotherapy drugs. The A allele of ABCG2 C421A may be a risk factor for progression of breast cancer in Kurdish patients. In addition, breast cancer patients with C allele of this polymorphism have weaker response to treatments with anthracyclines and Paclitaxol. © 2015, International Society of Oncology and BioMarkers (ISOBM).

Item Type: Article
Keywords: anthracycline; antineoplastic agent; breast cancer resistance protein; epidermal growth factor receptor 2; estrogen receptor; Ki 67 antigen; multidrug resistance protein 1; paclitaxel; progesterone receptor; ABCB1 protein, human; ABCG2 protein, human; antineoplastic agent; breast cancer resistance protein; multidrug resistance protein; tumor protein, ABCB1 gene; ABCG2 gene; adult; Article; breast cancer; cancer risk; cancer tissue; case control study; controlled study; female; gene frequency; genetic association; genetic risk; genotype; human; human tissue; immunohistochemistry; Kurd (people); major clinical study; oncogene; outcome assessment; polymerase chain reaction; priority journal; protein expression; restriction fragment length polymorphism; single nucleotide polymorphism; treatment response; Breast Neoplasms; ethnic group; genetic predisposition; genetics; Iran; middle aged; risk factor, Adult; Antineoplastic Agents; ATP Binding Cassette Transporter, Sub-Family G, Member 2; Breast Neoplasms; Case-Control Studies; Ethnic Groups; Female; Genetic Predisposition to Disease; Genotype; Humans; Immunohistochemistry; Iran; Middle Aged; Neoplasm Proteins; P-Glycoproteins; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors
Page Range: pp. 7901-7906
Journal or Publication Title: Tumor Biology
Volume: 37
Number: 6
Publisher: Springer Netherlands
Identification Number: 10.1007/s13277-015-4679-1
ISSN: 10104283
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/555

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