Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

In vitro activities of five antifungal agents against 199 clinical and environmental isolates of Aspergillus flavus, an opportunistic fungal pathogen

(2016) In vitro activities of five antifungal agents against 199 clinical and environmental isolates of Aspergillus flavus, an opportunistic fungal pathogen. Journal de Mycologie Medicale.

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Aspergillus flavus is the second leading cause of invasive and non-invasive aspergillosis, as well as the most common cause of fungal sinusitis, cutaneous infections, and endophthalmitis in tropical countries. Since resistance to antifungal agents has been observed in patients, susceptibility testing is helpful in defining the activity spectrum of antifungals and determining the appropriate drug for treatment. A collection of 199 clinical and environmental strains of Aspergillus flavus consisted of clinical (n = 171) and environmental (n = 28) were verified by DNA sequencing of the partial b-tubulin gene. MICs of amphotericin B, itraconazole, voriconazole, posaconazole, and MEC of caspofungin were determined in accordance with the Clinical and Laboratory Standards Institute M38-A2 document. Caspofungin, followed by posaconazole, exhibited the lowest minimum inhibitory concentrations (MIC). All isolates had caspofungin MEC90 (0.063 μg/ml) lower than the epidemiologic cutoff values, and 3.5 of the isolates had amphotericin B MIC higher than the epidemiologic cutoff values. However, their clinical effectiveness in the treatment of A. flavus infection remains to be determined. © 2016 Elsevier Masson SAS.

Item Type: Article
Keywords: amphotericin B; beta tubulin; caspofungin; itraconazole; posaconazole; voriconazole; amphotericin B; antifungal agent; caspofungin; echinocandin; itraconazole; lipopeptide; posaconazole; triazole derivative; voriconazole, Article; Aspergillus flavus; beta tubulin gene; controlled study; DNA sequence; fungal genetics; fungal strain; fungus isolation; in vitro study; Iran; minimum effective concentration; minimum inhibitory concentration; nonhuman; antifungal resistance; aspergillosis; Aspergillus flavus; classification; dose response; drug effects; environmental microbiology; growth, development and aging; human; microbial sensitivity test; microbiology; opportunistic infection, Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus flavus; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Echinocandins; Environmental Microbiology; Humans; Iran; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Opportunistic Infections; Triazoles; Voriconazole
Page Range: pp. 116-121
Journal or Publication Title: Journal de Mycologie Medicale
Volume: 26
Number: 2
Publisher: Elsevier Masson SAS
Identification Number: 10.1016/j.mycmed.2016.01.002
ISSN: 11565233
Depositing User: مهندس جمال محمودپور

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