Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Local Polyethylene Glycol in Combination with Chitosan Based Hybrid Nanofiber Conduit Accelerates Transected Peripheral Nerve Regeneration

(2016) Local Polyethylene Glycol in Combination with Chitosan Based Hybrid Nanofiber Conduit Accelerates Transected Peripheral Nerve Regeneration. Journal of Investigative Surgery.

Full text not available from this repository.

Official URL:


Objective: The incapability to promptly improve behavioral function after discontinuation of peripheral nerves is a current problem in clinical practice. Effect of local polyethylene glycol in combination with chitosan-based hybrid nanofiber conduit was assessed. Study Design: A 10-mm sciatic nerve defect was bridged using a chitosan-based hybrid nanofiber conduit (Chitosan) filled with phosphate-buffered saline. In authograft group (AUTO), a segment of sciatic nerve was transected and reimplanted reversely. In polyethylene glycol-treated group (CHIT/PEG), the conduit was filled with polyethylene glycol solution. The regenerated fibers were studied within 12 weeks after surgery. Results: The behavioral and functional tests confirmed faster recovery of the regenerated axons in PEG-treated group compared to Chitosan group (p <.05). The mean ratios of gastrocnemius muscles weight were measured. There was statistically significant difference between the muscle weight ratios of CHIT/PEG and Chitosan groups (p <.05). Morphometric indices of regenerated fibers showed number and diameter of the myelinated fibers were significantly higher in CHIT/PEG than in Chitosan. In immuohistochemistry, the location of reactions to S-100 in CHIT/PEG was clearly more positive than Chitosan group. Conclusion: polyethylene glycol solution when loaded in a chitosan-based hybrid nanofiber conduit resulted in acceleration of functional recovery and quantitative morphometric indices of sciatic nerve. © 2016, © Taylor & Francis Group, LLC.

Item Type: Article
Keywords: chitosan nanoparticle; macrogol; chitosan; macrogol derivative; nanofiber; neuroprotective agent, animal experiment; Article; controlled study; drug delivery system; gastrocnemius muscle; gluteus maximus muscle; male; motor performance; muscle mass; muscle reinnervation; myelin sheath; myelinated nerve; nerve function; nerve regeneration; nonhuman; phenotype; priority journal; rat; sciatic nerve; tensile strength; animal; autotransplantation; chemistry; combination drug therapy; convalescence; drug effects; human; nerve regeneration; Peripheral Nerve Injuries; procedures; surgery; Wistar rat, Animals; Chitosan; Drug Therapy, Combination; Humans; Male; Nanofibers; Nerve Regeneration; Neuroprotective Agents; Peripheral Nerve Injuries; Polyethylene Glycols; Rats; Rats, Wistar; Recovery of Function; Sciatic Nerve; Transplantation, Autologous
Page Range: pp. 167-174
Journal or Publication Title: Journal of Investigative Surgery
Volume: 29
Number: 3
Publisher: Taylor and Francis Ltd
Identification Number: 10.3109/08941939.2015.1098758
ISSN: 08941939
Depositing User: مهندس جمال محمودپور

Actions (login required)

View Item View Item