Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Alpha-Pinene Alleviates Motor Activity in Animal Model of Huntington's Disease via Enhancing Antioxidant Capacity

(2023) Alpha-Pinene Alleviates Motor Activity in Animal Model of Huntington's Disease via Enhancing Antioxidant Capacity. Neurochemical research.

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Huntington's disease (HD) is a progressive, neurodegenerative, and inherited disease. Antioxidants have been shown to be effective in slowing disease progression in animal models of HD and are under investigation in human clinical trials. alpha-pinene, a member of the monoterpene class, has been shown to exert antioxidant activity. Therefore, this study aimed to investigate the impact of alpha-pinene on animal model of HD. Thirty-two male Wistar rats received 3-Nitropropionic acid (3-NP) for induction of the disease model or treated with alpha-pinene + 3-NP in different groups. Motor skill, and biochemical evaluations to detect oxidant/antioxidant markers in rat cortex and striatum were performed in all groups. We found that alpha-pinene significantly improved 3-NP-induced changes in the body weight, rotarod activity, time taken to cross the narrow beam, and locomotor activity. Biochemical analysis revealed that alpha-pinene significantly decreased the 3NP-induced elevation in oxidant markers, nitrite, and malondialdehyde in both cortex and striatum. In addition, alpha-pinene counteracted the 3-NP-induced fall in antioxidant enzymes, including superoxide dismutase, catalase, and glutathione in the cortex and striatum. In conclusion, we found that alpha-pinene prevented the motor dysfunction induced by 3-NP in the animal model of Huntington's disease. Oxidants-antioxidant balance might be involved in the protective effect of alpha-pinene.

Item Type: Article
Keywords: Humans Rats Male Animals Antioxidants/pharmacology Rats, Wistar *Huntington Disease/chemically induced/drug therapy Motor Activity Lipid Peroxidation Models, Animal Oxidants Nitro Compounds/pharmacology Disease Models, Animal *Neuroprotective Agents/therapeutic use Behavior, Animal Huntington's disease Locomotor activity Oxidant/antioxidant balance alpha-Pinene
Page Range: pp. 1775-1782
Journal or Publication Title: Neurochemical research
Volume: 48
Number: 6
Depositing User: مهندس مهدی شریفی

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