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Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Therapeutic potency of curcumin for allergic diseases: A focus on immunomodulatory actions

(2022) Therapeutic potency of curcumin for allergic diseases: A focus on immunomodulatory actions. Biomedicine and Pharmacotherapy.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In light of increasing research evidence on the molecular mechanisms of allergic diseases, the crucial roles of innate and acquired immunity in the disease's pathogenesis have been well highlighted. In this respect, much attention has been paid to the modulation of unregulated and unabated inflammatory responses aiming to suppress pathologic immune responses in treating allergic diseases. One of the most important natural compounds with a high potency of immune modulation is curcumin, an active polyphenol compound derived from turmeric, Curcuma longa L. Curcumin's immunomodulatory action mainly arises from its interactions with an extensive collection of immune cells such as mast cells, eosinophils, epithelial cells, basophils, neutrophils, and lymphocytes. Up to now, there has been no detailed investigation of curcumin's immunomodulatory actions in allergic diseases. So, the present review study aims to prepare an overview of the immunomodulatory effects of curcumin on the pathologic innate immune responses and dysregulated functions of T helper (TH) subtypes, including TH1, TH2, TH17, and regulator T cells (Tregs) by gathering evidence from several studies of In-vitro and In-vivo. As the second aim of the present review, we also discuss some novel strategies to overcome the limitation of curcumin in clinical use. Finally, this review also assesses the therapeutic potential of curcumin regarding its immunomodulatory actions in allergic diseases. © 2022 The Authors

Item Type: Article
Keywords: Allergic disease, Curcumin Immune modulation, Turmeric curcumin allergic disease drug efficacy drug formulation drug potency human immune response immunomodulation immunopathogenesis innate immunity nonhuman regulatory T lymphocyte Review Th1 cell Th17 cell Th2 cell eosinophil hypersensitivity immunity mast cell Eosinophils Humans Mast Cells
Journal or Publication Title: Biomedicine and Pharmacotherapy
Volume: 154
Depositing User: مهندس مهدی شریفی
URI: http://eprints.muk.ac.ir/id/eprint/5792

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