Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF-κB, JAK/STAT, and MAPK signaling pathways

(2022) Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF-κB, JAK/STAT, and MAPK signaling pathways. Phytotherapy Research.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Three main inflammatory signaling pathways include nuclear factor-κB (NF-κB), Janus kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen-activated protein kinases (MAPKs) play crucial roles in inducing, promoting, and regulating inflammatory responses in the immune system. Importantly, the breakdown of mechanisms that tightly regulate inflammatory signaling pathways can be the underlying cause of uncontrolled inflammatory responses and be associated with the generation and development of several inflammatory diseases. Hence, therapeutic strategies targeting inflammatory signaling pathways and their downstream components may promise to treat inflammatory diseases. Studies over the past two decades have provided important information on the polytrophic pharmacological and biochemical properties of berberine (BBR) as a naturally occurring compound, such as antioxidant, antitumor, antimicrobial, and antiinflammatory activates. Interestingly, the modulatory effects of BBR on inflammatory signaling cascades, which lead to the inhibition of inflammation, have been widely investigated in several in vitro and in vivo studies. For the first time, herein, this comprehensive review attempts to put together these studies and provide important insight into the modulatory effects of BBR on NF-κB, JAKs/STATs, and MAPKs signaling pathways in vitro in various types of immune cells and in vivo in several experimental inflammatory diseases. As the second achievement of this review, we also explore the therapeutic efficacy and antiinflammatory effects of BBR regarding its modulatory action. © 2022 John Wiley & Sons Ltd.

Item Type: Article
Keywords: berberine inflammation JAK MAPK NF-κB STAT B7 antigen CD40 antigen CD86 antigen immunoglobulin enhancer binding protein interleukin 13 interleukin 17 interleukin 1beta interleukin 4 interleukin 5 interleukin 6 Janus kinase mitogen activated protein kinase monocyte chemotactic protein 1 prostaglandin E2 STAT protein tumor necrosis factor antiinflammatory agent antiinflammatory activity antimicrobial activity antineoplastic activity antioxidant activity clinical effectiveness coronavirus disease 2019 cytokine production cytokine release human immune system immunocompetent cell immunomodulation JAK-STAT signaling MAPK signaling NF kB signaling nonhuman protein expression protein targeting regulatory T lymphocyte Review Th1 cell Th17 cell ulcerative colitis upregulation metabolism signal transduction Anti-Inflammatory Agents NF-kappa B
Page Range: pp. 1216-1230
Journal or Publication Title: Phytotherapy Research
Volume: 36
Number: 3
Depositing User: مهندس مهدی شریفی
URI: http://eprints.muk.ac.ir/id/eprint/5866

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