Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Genotyping of clinical and environmental Aspergillus flavus isolates from Iran using microsatellites

(2016) Genotyping of clinical and environmental Aspergillus flavus isolates from Iran using microsatellites. Mycoses.

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Aspergillus flavus is the second most important Aspergillus species causing human infections in tropical countries. Despite an increasing number of infections of A. flavus in Iran, the molecular epidemiology of clinical and environmental strains has not been well studied. We used a panel of nine microsatellite markers to analyse the genetic relatedness of A. flavus. Microsatellite typing of 143 (n = 119 clinical and n = 24 environmental) isolates demonstrated 118 different genotypes. A possible outbreak at a pulmonary ward was discovered. The discriminatory power for the individual markers ranged from 0.4812 to 0.9457 and the panel of all nine markers combined yielded a diversity index of 0.9948. This high-resolution typing method assists in better understanding of the molecular epidemiology of A. flavus. © 2016 Blackwell Verlag GmbH.

Item Type: Article
Keywords: fungal DNA; microsatellite DNA, Article; Aspergillus flavus; DNA isolation; fungus isolation; genetic variability; genotype; Iran; microsatellite marker; molecular epidemiology; molecular typing; multiplex polymerase chain reaction; nonhuman; priority journal; species diversity; sporogenesis; aspergillosis; Aspergillus flavus; classification; environmental microbiology; evaluation study; genetics; genotyping technique; human; isolation and purification; microbiological examination; microbiology; molecular epidemiology; procedures, Aspergillosis; Aspergillus flavus; Environmental Microbiology; Genotyping Techniques; Humans; Iran; Microsatellite Repeats; Molecular Epidemiology; Mycological Typing Techniques
Page Range: pp. 220-225
Journal or Publication Title: Mycoses
Volume: 59
Number: 4
Publisher: Blackwell Publishing Ltd
Identification Number: 10.1111/myc.12451
ISSN: 09337407
Depositing User: مهندس جمال محمودپور

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