Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Associations of vitamin D receptor rs1544410 polymorphism with type 1 diabetes mellitus risk: Systematic review and meta-analysis

(2021) Associations of vitamin D receptor rs1544410 polymorphism with type 1 diabetes mellitus risk: Systematic review and meta-analysis. Meta Gene.

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Background: Inconclusive findings on the association of polymorphisms in vitamin D receptors (VDR) with the risk of type 1 diabetes mellitus (T1DM) have been obtained in several studies. Aim: The present meta-analysis was conducted to comprehensively examine the effects of rs7975232, rs1544410, rs2228570, and rs731236 polymorphisms in the VDR gene on the risk of T1DM in the Eastern Mediterranean Region (EMRO) population. Methods: The PubMed, Scopus, Web of Science, and Google Scholar databases were searched for related literature published up to May 2021. Pooled odds ratios (ORs) with 95 confidence intervals (CIs) were calculated to measure the strength of the associations. The Newcastle–Ottawa Scale was used to the assessment of the methodological quality of each study. Meta-regression and subgroup analysis were performed to find the potential sources of heterogeneity. Results: Nine studies consisting of 1618 subjects were included in this study. A protective association for rs1544410 polymorphism under allelic model OR = 0.597, 95% CI (0.360–0.989), P = 0.045, codominant model OR = 0.432, 95% CI (0.220–0.851), P = 0.015, and dominant model OR = 0.460, 95% CI (0.257–0.824), P = 0.009, and a predisposing association under recessive model OR = 1.607, 95% CI (1.017–2.539), P = 0.042 with T1DM risk was found in selected population. However, no significant associations between rs7975232, rs2228570 and rs731236 and T1DM risk were observed (P > 0.05). Conclusion: The present meta-analysis suggested that rs1544410 polymorphism might be associated with risk of T1DM in the EMRO population. © 2021

Item Type: Article
Keywords: Association Genetic polymorphism Meta-analysis Type 1 diabetes mellitus Vitamin D receptor exon gene gene frequency genetic association genetic model genetic susceptibility insulin dependent diabetes mellitus intron meta analysis pathogenicity polymerase chain reaction restriction fragment length polymorphism promoter region Review risk factor single nucleotide polymorphism systematic review
Journal or Publication Title: Meta Gene
Volume: 30
Depositing User: مهندس مهدی شریفی

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