Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Synergistic effect of cumin (Cuminum cyminum L.) decoction alongside with three-drug and four-drug treatment protocols on helicobacter pylori eradication

(2021) Synergistic effect of cumin (Cuminum cyminum L.) decoction alongside with three-drug and four-drug treatment protocols on helicobacter pylori eradication. Journal of Reports in Pharmaceutical Sciences.

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Background: Helicobacter pylori is a major cause of peptic ulcer. On the other hand, cumin (Cuminum cyminum L.) is an effective medicinal plant for the treatment of gastrointestinal disease in traditional Persian medicine. This study aimed at investigating the synergistic effect of the decoction of cumin with the three- and four-drug protocols against H. pylori in patients with peptic ulcer. Patients with peptic ulcer infected with H. pylori were treated with cumin decoction, three- and four-drug protocols, and their co-administration to eradicate H. pylori. Materials and Methods: Patients were randomly divided into five groups, including group (1) omeprazole with cumin decoction, (2) cumin decoction with the three-protocol treatment, (3) cumin decoction with the four-drug protocol treatment, and (4 and 5) three- and four-drug protocols alone. The cumin fruit powder was given to patients in 3-g packages and decoction was prepared according to the traditional Iranian medicine guidelines. H. pylori eradication was measured by the 14C–urea breath test (14C-UBT) after 4 weeks of intervention. The Kolmogorov–Smirnov test, χ2 test, logistic regression, and ANOVA (SPSS, 11.5) were used for data analyses. Results: In total, 75 patients (48 male and 27 female patients) participated in this study. The results showed that eradication of H. pylori was observed in all five study groups. Eradication of H. pylori in cumin decoction with the three-drug protocol group was more than the other groups (85.72), although this difference was not statistically significant. In addition, this eradication was 61.5 in the cumin + omeprazole group, while the H. pylori eradication rates for the three-drug and four-drug protocols were 77.8 and 58.33, respectively. Conclusions: The results showed that decoction of cumin could be used as a complementary treatment alongside conventional medicine therapy to increase the H. pylori eradication. © 2021 Journal of Reports in Pharmaceutical Sciences.

Item Type: Article
Keywords: Cuminum cyminum L Four-drug treatment protocol Helicobacter pylori eradication Peptic ulcer Three-drug treatment protocol amoxicillin bismuth citrate clarithromycin cumin decoction essential oil metronidazole omeprazole plant extract unclassified drug adult allopathy Article bacterial clearance breath analysis clinical trial controlled clinical trial controlled study cumin drug potentiation female four-drug treatment gastrointestinal disease Helicobacter infection Helicobacter pylori human Kolmogorov Smirnov test lung insufficiency major clinical study male medicinal plant middle aged mortality polymerase chain reaction practice guideline synergistic effect three-drug treatment treatment outcome urea breath test
Page Range: pp. 66-70
Journal or Publication Title: Journal of Reports in Pharmaceutical Sciences
Volume: 10
Number: 1
Depositing User: مهندس مهدی شریفی

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