Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis

(2016) Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis. Allergologia et Immunopathologia.

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Background: Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associations of five polymorphisms of IL-10 and TGF-β genes with AR. Materials and methods: Ninety-eight patients with AR along with 140 healthy volunteers with no history of AR and with the same ethnicity of the patients were recruited in this study. Genotyping was done for three polymorphisms in promoter region of IL-10 gene (rs1800896, rs1800871, rs1800872), and two polymorphisms in the exonic region of TGF-β1 gene (rs1982037, rs1800471) using PCR sequence-specific-primers method. Results: A allele and AA genotype in rs1800896 of IL-10 and TT genotype in rs1982037 in TGF-β were significantly less frequent in the patients than in controls. While the C allele and the CG genotype in rs1800471 in TGF-β1 were associated with a higher susceptibility to AR. C/C and T/C haplotypes (rs1982037, rs1800471) in TGF-β1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL-10 gene were found with higher frequencies in patients than controls. Patients with CC genotype in rs1800871 in Il-10 had significantly lower levels of IgE. Conclusion: We found that certain genetic variants in IL-10 and TGF-β polymorphisms were associated with susceptibility to AR as well as some clinical parameters in the patients with AR. © 2015 SEICAP.

Item Type: Article
Keywords: interleukin 10; transforming growth factor beta; interleukin 10; transforming growth factor beta, adolescent; adult; allele; allergic rhinitis; Article; child; controlled study; ethnicity; female; gene frequency; genotype; haplotype; human; major clinical study; male; polymerase chain reaction; single nucleotide polymorphism; allergic rhinitis; case control study; genetic association study; genetic predisposition; genetics; Iran; preschool child; single nucleotide polymorphism; young adult, Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-10; Iran; Male; Polymorphism, Single Nucleotide; Rhinitis, Allergic; Transforming Growth Factor beta; Young Adult
Page Range: pp. 125-130
Journal or Publication Title: Allergologia et Immunopathologia
Volume: 44
Number: 2
Publisher: Elsevier Doyma
Identification Number: 10.1016/j.aller.2015.05.010
ISSN: 03010546
Depositing User: مهندس جمال محمودپور

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