Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Effect of vitamin C supplementation in the prevention of atrial fibrillation

(2016) Effect of vitamin C supplementation in the prevention of atrial fibrillation. Tehran University Medical Journal.

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Background: Recently, the role of inflammation and oxidative stress in the pathophysiology of atrial fibrillation (AF) after cardiac surgery has been emphasized. Vitamin C as an antioxidant important role in reducing the incidence of postoperative atrial fibrillation. This study aimed to investigate, administration of vitamin C, as a way to reduce the incidence of atrial fibrillation after coronary bypass surgery. Methods: In this double-blind clinical study, 290 patients in Rajaee Heart Center, from March 2013 to December 2014 who underwent coronary artery bypass surgery were randomly divided into intervention and control groups to receive vitamin C and placebo. The intervention group before the surgery in the operating room received 2 grams of vitamin C intravenously then one gram per day for four days prior to surgery. After the operation, the two groups were compared in terms of the following: Atrial and ventricular arrhythmias after surgery, ICU stay and hospital stay and duration of intubation. Results: 113 cases and 177 controls (191 men and 99 women) with a mean age of 5.40±14.40 years in both groups (vitamin C and placebo) were enrolled. The incidence of postoperative atrial fibrillation was 55 in the placebo group to 35 in the vitamin C group decreased (P= 0.001). Duration of intubation in the intervention group 11.8 and the control group was 14.14 hours (P= 0.004). The amount of drainage was lower in vitamin C group (P= 0.003). Vitamin C had no effect on the rates of hospital and ICU stay (P= 0.075). There was no significant reduction in threatening arrhythmia (VT) and VF in this period (P= 0.159). Conclusion: Vitamin C supplements may reduce atrial fibrillation after coronary artery bypass surgery also can improve conditions such as reducing the duration of intubation. With regard to the safety, these supplements can be recommended for the prevention of atrial fibrillation before coronary artery bypass surgery. © 2016, Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: ascorbic acid; placebo, adult; Article; atrial fibrillation; controlled study; coronary artery bypass surgery; double blind procedure; female; heart atrium arrhythmia; heart ventricle arrhythmia; human; incidence; intensive care; intubation; length of stay; major clinical study; male; middle aged; postoperative period; randomized controlled trial; vitamin supplementation
Page Range: pp. 791-797
Journal or Publication Title: Tehran University Medical Journal
Volume: 73
Number: 11
Publisher: Tehran University of Medical Sciences
ISSN: 16831764
Depositing User: مهندس جمال محمودپور

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