Abstract

Background and Aim: There have been reports of beneficial effects of Cinnamomum extract on the respiratory disorders, digestive problems, menstrual pain and inflammatory diseases such as arthritis. The aim of this study was to evaluate the analgesic effects of hydroalcoholic extract of Cinnamomum in rats by using plantar test. Material and Methods: Wistar male rats were divided into six groups (n=8) randomly. The rats received either hydroalcoholic extract of Cinnamomum (200, 400, mg/kg) alone, or in combination with naloxone or flumazenil intraperitoneally and after 30, 60 and 90 min, the analgesic effects of the extracts was assessed by means of plantar test. Results: The results showed that injection of hydroalcoholic extract of Cinnamomum (400 mg/kg, ip) increased significantly the time delay in response to thermal pain inducing effect in pain model of plantar test at 60 (P <0.05) and 90 (P <0.01) min after injection compared to the control group. In addition, we found no significant differences between experimental and control groups in relation to the analgesic effect of 400 mg/kg of Cinnamomum extract, with naloxone or flumazenil and the analgesic effect of Cinnamomum extract was blocked. Conclusion: Our findings confirmed the analgesic effect of Cinnamomum extract. Considering the effects of flumazenil and naloxone on inhibition of the Cinnamomum analgesia, it seems that opioidergic and GABAergic pathways may be involved in the mechanism of Cinnamomum analgesic effect. © 2016, Kurdistan University of Medical Sciences. All rights reserved.