Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Acute administration of pioglitazone attenuates morphine withdrawal syndrome in rat: a novel role of pioglitazone

(2015) Acute administration of pioglitazone attenuates morphine withdrawal syndrome in rat: a novel role of pioglitazone. Drug research.

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BACKGROUND: Long-term exposure to opiates such is morphine induces dependence. PURPOSE: The purpose of the present study was to investigate the effects of the acute administration of pioglitazone, a selective agonist of peroxisome proliferator activated receptors gamma (PPAR-γ), on the morphine withdrawal syndrome in the rat. METHODS: Male Wistar rats (200-250�g) were selected randomly and divided into 8 groups including 2 non-dependent groups and 6 morphine-dependent groups which were received additive doses of morphine subcutaneously at an interval of 12�h for 9 continuous days. On the ninth day, only the morning dose of morphine was injected and 2�h later, morphine withdrawal was precipitated by naloxone and then ten distinct withdrawal behaviors were recorded for 45�min. Pioglitazone (5, 10, 20 and 40�mg/kg) was gavaged 2�h before naloxone injection. It is worth noting that 1�h before the pioglitazone (40�mg/kg) gavage, GW-9662 (2�mg/kg), a selective PPAR-γ antagonist, was administrated in order to evaluate the possible role of the PPAR-γ. RESULT AND DISCUSSION: The results of this study showed that administration of pioglitazone (40�mg/kg) decreased all withdrawal signs and the statistical analysis indicated that pioglitazone could attenuate the total withdrawal scores significantly. Administration of GW-9662 had no significant effect on pioglitazone attenuation effect on morphine withdrawal symptoms.Taking together, it was concluded that acute oral administration of pioglitazone prevented naloxone-precipitated withdrawal symptoms and GW-9662 could not revert its effect on morphine withdrawal syndrome. It seems that pioglitazone suppresses morphine withdrawal syndrome through PPAR-γ independent mechanisms. © Georg Thieme Verlag KG Stuttgart · New York.

Item Type: Article
Keywords: 2,4 thiazolidinedione derivative; 2-chloro-5-nitrobenzanilide; anilide; morphine; naloxone; narcotic analgesic agent; peroxisome proliferator activated receptor gamma; pioglitazone, agonists; animal; antagonists and inhibitors; male; metabolism; Morphine Dependence; rat; Substance Withdrawal Syndrome; Wistar rat, Analgesics, Opioid; Anilides; Animals; Male; Morphine; Morphine Dependence; Naloxone; PPAR gamma; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Thiazolidinediones
Page Range: pp. 113-118
Journal or Publication Title: Drug research
Volume: 65
Number: 3
Identification Number: 10.1055/s-0033-1364035
ISSN: 21949387
Depositing User: مهندس جمال محمودپور

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