Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Effect of memantine on cognitive performance in patients under electroconvulsive therapy A double-blind randomized clinical trial

(2015) Effect of memantine on cognitive performance in patients under electroconvulsive therapy A double-blind randomized clinical trial. Clinical Neuropharmacology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Objectives: Various strategies such as adding cholinesterase inhibitors are used to reduce cognitive impairments during electroconvulsive therapy. In this study, we aimed to assess the effectiveness and safety of memantine as an N-methyl-D-aspartate receptor antagonist in the prevention of cognitive deficits due to ECT. Methods: Thirty-eight adult patients with various mental disorders were randomized to memantine (10 mg/day initially and 20 mg/day at the end of the first week) or placebo during the ECT period. Mini Mental Status Examination, Digit Span Subtest, and backward memory span ofWechsler Adult Intelligence Scale were used to assess the cognitive functions 24 hours before and after ECT. Subjective ratings of side effects were obtained in the first, second, and fourth week of the treatment. Results: The mean Mini Mental Status Examination score relatively increased in the intervention group showing a significant improvement with memantine (P < 0.001). The direct digit span had decreased in the control group, whereas no significant change was observed in the intervention group (P < 0.001). Backward memory span test showed a decrease in the control group after the ECT sessions, whereas a relative increase was observed in the intervention group (P = 0.001). The most frequently reported side effects in the intervention group did not differ significantly from the control group. Conclusions: This initial study showed that cognitive performance was enhanced in patients receiving memantine during ECT, indicating the possible role of the glutamatergic system in creating ECT-induced deficits. Larger long-term studies are necessary for understanding the role of the glutamatergic system in these disorders. © 2015 Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Article
Keywords: memantine; amino acid receptor blocking agent; memantine, adult; Article; Backward Memory Span; bipolar I disorder; clinical article; cognition; cognitive defect; confusion; controlled study; Digit Span Subtest; double blind procedure; drug efficacy; drug safety; electroconvulsive therapy; female; headache; human; major depression; male; mental disease assessment; Mini Mental State Examination; priority journal; randomized controlled trial; restlessness; schizoaffective psychosis; schizophrenia; Wechsler adult intelligence scale; adverse effects; Cognition Disorders; electroconvulsive therapy; Mental Disorders; middle aged; neuropsychological test; psychological rating scale; treatment outcome; young adult, Adult; Cognition Disorders; Double-Blind Method; Electroconvulsive Therapy; Excitatory Amino Acid Antagonists; Female; Humans; Male; Memantine; Mental Disorders; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Treatment Outcome; Young Adult
Page Range: pp. 236-240
Journal or Publication Title: Clinical Neuropharmacology
Volume: 38
Number: 6
Publisher: Lippincott Williams and Wilkins
Identification Number: 10.1097/WNF.0000000000000109
ISSN: 03625664
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/796

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