Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Antidepressant effect of combined ketamine and electroconvulsive therapy on patients with major depressive disorder: A randomized trial

(2015) Antidepressant effect of combined ketamine and electroconvulsive therapy on patients with major depressive disorder: A randomized trial. Iranian Journal of Psychiatry and Behavioral Sciences.

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Abstract

Background: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response. Objectives: We aimed to determine the effect of Ketamine as a synergistic antidepressant and anesthetic agent on MDD in electroconvulsive therapy (ECT). Patients and Methods: Twenty-two patients with MDD received Ketamine and Propofol as anesthetic agents compared with 20 patients as the control group who received Propofol in a double-blind randomized clinical trial. The Hamilton rating scale for depression was used to determine the changes in symptoms severity during ECT and a 2-week follow-up. Results: Both groups showed a reduction in depression severity, but there was no significant difference between the groups in the recovery process (P = 0.92). However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042). Conclusions: This study could not show the effect of Ketamine on depression recovery in a 2-week follow-up period. Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT. © 2015, Mazandaran University of Medical Sciences.

Item Type: Article
Keywords: Amines; Anesthetics; Delay control systems; Electrotherapeutics; Recovery; Time delay, Antidepressants; Cognitive performance; Electroconvulsive therapy; Ketamine; Major depressive disorder (MDD); Randomized clinical trials; Randomized trial; Recovery process, Patient treatment, atropine; ketamine; propofol; suxamethonium, adult; aged; agitation; antidepressant activity; Article; clinical article; cognition; controlled study; disease severity; double blind procedure; drug potentiation; DSM-IV-TR; electroconvulsive therapy; female; hallucination; Hamilton Depression Rating Scale; human; major depression; male; muscle relaxation; randomized controlled trial; side effect
Journal or Publication Title: Iranian Journal of Psychiatry and Behavioral Sciences
Volume: 9
Number: 3
Publisher: Mazandaran University of Medical Sciences
Identification Number: 10.17795/ijpbs-1578
ISSN: 17358639
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/798

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