Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Effect of systemic administration of mefloquine on morphine- induced withdrawal symptoms in rats

(2015) Effect of systemic administration of mefloquine on morphine- induced withdrawal symptoms in rats. Journal of Mazandaran University of Medical Sciences.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background and purpose: The exact mechanisms of morphine dependence and withdrawal syndrome remain unclear. Many studies have been performed to find a drug for prevention of withdrawal symptoms. The aim of this study was to evaluate the effect of mefloquine (a gap junction inhibitor) on morphine withdrawal symptoms in male rats. Materials and methods: In an experimental study, adult male Wistar rats weighting 225± 275 g were randomly divided into 6 groups (n=8 per group). In order to induce dependency, additive doses of morphine were injected subcutaneously for 13 days. At day 13, after the last dose of morphine, saline (1 ml/kg: control) or mefloquine (5, 15, 30 mg/kg) were injected intraperitoneally. After 30 min, all groups received naloxone (4 mg/kg, ip) and the withdrawal signs including jumping, rearing, genital grooming, abdominal writhing, body grooming and wet dog shake, were recorded for 60 minutes. Results: The results showed that mefloquine in all used doses decreased the withdrawal symptoms and the total withdrawal scores compared to control group. Conclusion: Mefloquine was found effective as a gap junction inhibitor in decreasing the symptoms of morphine withdrawal syndrome. © 2015 Mazandaran University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: mefloquine; morphine, adult; animal experiment; animal model; Article; controlled study; experimental study; male; nonhuman; rat; withdrawal syndrome
Page Range: pp. 86-93
Journal or Publication Title: Journal of Mazandaran University of Medical Sciences
Volume: 25
Number: 121
Publisher: Mazandaran University of Medical Sciences
ISSN: 17359279
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/821

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