(2015) Antibody against α-gliadin 33-mer peptide: Is the key initiating factor for development of multiple sclerosis during gluten sensitivity? Journal of Medical Hypotheses and Ideas.
Full text not available from this repository.
Abstract
Despite great advances in clarifying the pathogenesis of multiple sclerosis (MS), the exact underlying mechanism has not been definitely established. However, the responsibility of cross-reactive antibodies as the initiating factor in MS pathogenesis is a novel idea. Recently, an antibody against-α-gliadin 33-mer peptide which is found in most patients with gluten sensitivity have shown to cross-react significantly with various neural antigens including asialoganglioside, synapsin, and myelin basic protein (MBP). Furthermore, evidence indicates that IL-17, circulating immune complexes and even antibodies produced during gluten sensitivity can contribute to blood-brain barrier (BBB) permeability. Accordingly, extravasation of these anti-α-gliadin antibodies (AGA; especially IgG isotype) through the impaired BBB thought to target asialoganglioside, synapsin, and MBP in neurons. This opsonization may trigger a series of cascade pathways including complement activation, antibody-dependent microglial cytotoxicity against neurons, secretion of inflammatory mediators, myelin sheath damage, chemokine expression, CNS inflammation, BBB disruption and then leukocyte infiltration. The present hypothesis introduces a new antibody-dependent alternative pathway which may lead to multiple sclerosis (MS) during gluten sensitivity. © 2015 Tehran University of Medical Sciences.
Item Type: | Article |
---|---|
Keywords: | alpha gliadin antibody; cell adhesion molecule; Fc receptor; gangliotetraosylceramide; gluten; interleukin 17; interleukin 1beta; interleukin 6; monocyte chemotactic protein 1; myelin basic protein; prostaglandin E2; protein antibody; synapsin; tumor necrosis factor alpha; unclassified drug, antibody dependent cellular cytotoxicity; antigen binding; Article; binding affinity; blood brain barrier; cell activation; cell infiltration; complement system; cytokine production; cytokine release; food allergy; human; leukocyte; microglia; multiple sclerosis; nonhuman; pathogenesis; phagocytosis; protein expression; protein interaction |
Page Range: | pp. 38-44 |
Journal or Publication Title: | Journal of Medical Hypotheses and Ideas |
Volume: | 9 |
Number: | 1 |
Publisher: | Tehran University of Medical Sciences (TUMS) |
Identification Number: | 10.1016/j.jmhi.2015.02.002 |
ISSN: | 22517294 |
Depositing User: | مهندس جمال محمودپور |
URI: | http://eprints.muk.ac.ir/id/eprint/825 |
Actions (login required)
View Item |