Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Antibody against α-gliadin 33-mer peptide: Is the key initiating factor for development of multiple sclerosis during gluten sensitivity?

(2015) Antibody against α-gliadin 33-mer peptide: Is the key initiating factor for development of multiple sclerosis during gluten sensitivity? Journal of Medical Hypotheses and Ideas.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Despite great advances in clarifying the pathogenesis of multiple sclerosis (MS), the exact underlying mechanism has not been definitely established. However, the responsibility of cross-reactive antibodies as the initiating factor in MS pathogenesis is a novel idea. Recently, an antibody against-α-gliadin 33-mer peptide which is found in most patients with gluten sensitivity have shown to cross-react significantly with various neural antigens including asialoganglioside, synapsin, and myelin basic protein (MBP). Furthermore, evidence indicates that IL-17, circulating immune complexes and even antibodies produced during gluten sensitivity can contribute to blood-brain barrier (BBB) permeability. Accordingly, extravasation of these anti-α-gliadin antibodies (AGA; especially IgG isotype) through the impaired BBB thought to target asialoganglioside, synapsin, and MBP in neurons. This opsonization may trigger a series of cascade pathways including complement activation, antibody-dependent microglial cytotoxicity against neurons, secretion of inflammatory mediators, myelin sheath damage, chemokine expression, CNS inflammation, BBB disruption and then leukocyte infiltration. The present hypothesis introduces a new antibody-dependent alternative pathway which may lead to multiple sclerosis (MS) during gluten sensitivity. © 2015 Tehran University of Medical Sciences.

Item Type: Article
Keywords: alpha gliadin antibody; cell adhesion molecule; Fc receptor; gangliotetraosylceramide; gluten; interleukin 17; interleukin 1beta; interleukin 6; monocyte chemotactic protein 1; myelin basic protein; prostaglandin E2; protein antibody; synapsin; tumor necrosis factor alpha; unclassified drug, antibody dependent cellular cytotoxicity; antigen binding; Article; binding affinity; blood brain barrier; cell activation; cell infiltration; complement system; cytokine production; cytokine release; food allergy; human; leukocyte; microglia; multiple sclerosis; nonhuman; pathogenesis; phagocytosis; protein expression; protein interaction
Page Range: pp. 38-44
Journal or Publication Title: Journal of Medical Hypotheses and Ideas
Volume: 9
Number: 1
Publisher: Tehran University of Medical Sciences (TUMS)
Identification Number: 10.1016/j.jmhi.2015.02.002
ISSN: 22517294
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/825

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