Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Emerging role of miR-372 and miR-101a in head and neck squamous cell carcinoma

(2020) Emerging role of miR-372 and miR-101a in head and neck squamous cell carcinoma. Clinical Laboratory.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: microRNAs (miRNAs) have an important role in cancer development and progression. It has been shown that miR-372 and miR-101 are involved in cancer progression. In the present study we evaluated expres-sions of these miRNAs and their serum levels in patients with head and neck squamous cell carcinoma (HNSCC) and controls. Methods: We conducted this case-control study on 60 patients with HNSCC and 30 controls. Patients were diagnosed by histological assessments of their tissues. Expressions of EGFR, PTEN, PI3K/CA, miR-372, and miR-101a were evaluated in the tissues, along with serum levels of the miRNAs. Results: Tissue expression of PTEN decreased in HNSCC, and expressions of EGFR and PI3K increased in HNSCC tissues compared to the controls. Tissue expressions of miR-372 increased and miR-101a decreased in HNSCC tissues compared to the controls. We observed significantly lower serum levels of miR-101a in patients; however, these findings for miR-372 were not significant. A strong correlation existed between serum levels and tissue expression of miR-101a. Notably, miR-101a serum levels showed good sensitivity and specificity for diagnosis of HNSCC. Conclusions: The results showed that HNSCC patients had higher tissue expression of miR-372 and lower expression of miR-101a. Also, serum levels of miR-101a were lower in HNSCC patients. We observed that miR-101a had good sensitivity and specificity for diagnosis of HNSCC. The present study suggested that miR-101a could be a potential biomarker for HNSCC. © 2020 Verlag Klinisches Labor GmbH. All rights reserved.

Item Type: Article
Keywords: miR-372; miR-101a;squamous cell carcinoma
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Clinical Biochemistry
Page Range: pp. 579-587
Journal or Publication Title: Clinical Laboratory
Journal Index: ISI, Pubmed, Scopus
Volume: 66
Number: 4
Publisher: Verlag Klinisches Labor GmbH
Identification Number: 10.7754/CLIN.LAB.2019.190734
ISSN: 14336510
Depositing User: دکتر علیرضا غریب
URI: http://eprints.muk.ac.ir/id/eprint/4693

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