(2020) Emerging role of miR-372 and miR-101a in head and neck squamous cell carcinoma. Clinical Laboratory.
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Abstract
Background: microRNAs (miRNAs) have an important role in cancer development and progression. It has been shown that miR-372 and miR-101 are involved in cancer progression. In the present study we evaluated expres-sions of these miRNAs and their serum levels in patients with head and neck squamous cell carcinoma (HNSCC) and controls. Methods: We conducted this case-control study on 60 patients with HNSCC and 30 controls. Patients were diagnosed by histological assessments of their tissues. Expressions of EGFR, PTEN, PI3K/CA, miR-372, and miR-101a were evaluated in the tissues, along with serum levels of the miRNAs. Results: Tissue expression of PTEN decreased in HNSCC, and expressions of EGFR and PI3K increased in HNSCC tissues compared to the controls. Tissue expressions of miR-372 increased and miR-101a decreased in HNSCC tissues compared to the controls. We observed significantly lower serum levels of miR-101a in patients; however, these findings for miR-372 were not significant. A strong correlation existed between serum levels and tissue expression of miR-101a. Notably, miR-101a serum levels showed good sensitivity and specificity for diagnosis of HNSCC. Conclusions: The results showed that HNSCC patients had higher tissue expression of miR-372 and lower expression of miR-101a. Also, serum levels of miR-101a were lower in HNSCC patients. We observed that miR-101a had good sensitivity and specificity for diagnosis of HNSCC. The present study suggested that miR-101a could be a potential biomarker for HNSCC. © 2020 Verlag Klinisches Labor GmbH. All rights reserved.
Item Type: | Article |
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Keywords: | miR-372; miR-101a;squamous cell carcinoma |
Subjects: | QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body |
Divisions: | Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Clinical Biochemistry |
Page Range: | pp. 579-587 |
Journal or Publication Title: | Clinical Laboratory |
Journal Index: | ISI, Pubmed, Scopus |
Volume: | 66 |
Number: | 4 |
Publisher: | Verlag Klinisches Labor GmbH |
Identification Number: | 10.7754/CLIN.LAB.2019.190734 |
ISSN: | 14336510 |
Depositing User: | دکتر علیرضا غریب |
URI: | http://eprints.muk.ac.ir/id/eprint/4693 |
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