Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Preparation of etoposide loaded poly butyl cyano acrylate nanoparticles and it's effect on human brain carcinoma cells BE(2)-C

(2016) Preparation of etoposide loaded poly butyl cyano acrylate nanoparticles and it's effect on human brain carcinoma cells BE(2)-C. Der Pharmacia Lettre.

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The main purpose of this studywas preparation of a pharmaceutical formulation with etoposide loaded Poly Butyl Cyano Acrylate (PBCA) nanoparticles and evaluation of its effect on brain cancer. Etoposide loaded nanocarrier was synthesized using micro-emulsion polymerization method and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, BE (2)-C brain cell line was used to determine the rate of nanocarrieretoposide cytotoxicity. Etoposide loaded nanoparticles were characterized and size and zeta potential of nanoparticles containing drugs were measured as 225.3±21.7 nm and -26.3 ±1.5 mv, respectively. Drug loading and encapsulation values were estimated 8.7±0.15 and 97.3±2.1, respectively. The release amount of drug from PBCA nanoparticles indicated the retention strength corresponding to the formulation. Cytotoxicity studies showed that the cell toxicity effect of drug loaded PBCA nanoparticles is almost two times higher than the free drugs. Finally, it was found that the obtained formulation has a proper stability and drug maintain its stability after storage in 37° for two months. According to the obtained results, this nanoparticle has a potential to be used as a drug delivery system.

Item Type: Article
Keywords: etoposide; nanocarrier; nanoparticle; poly butyl cyano acrylate nanoparticle; unclassified drug, Article; brain tumor cell line; cancer cell destruction; concentration (parameters); controlled study; cytotoxicity; drug effect; drug formulation; drug release; drug synthesis; human; human cell; IC50; microemulsion; nanoencapsulation; particle size; polymerization; zeta potential
Page Range: pp. 96-100
Journal or Publication Title: Der Pharmacia Lettre
Volume: 8
Number: 16
Publisher: Scholars Research Library
ISSN: 09755071
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/698

Actions (login required)

View Item View Item