Repository of Research and Investigative Information

Repository of Research and Investigative Information

Kurdistan University of Medical Sciences

Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial

(2015) Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial. Pharmacological Reports.

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Introduction Major Depressive Disorder (MDD) is known as one of the most common psychiatric disorders in patients with multiple sclerosis (MS). In recent years, zinc has been found to have beneficial effects on psychopathology and the therapy of depression. The aim of the present study was to examine the effect of zinc supplement on depression and neurological signs in patients with MS. Methods The present randomized, double-blind, placebo-controlled clinical trial was performed on 43 patients with MS and who also demonstrated MDD based on the Beck questionnaire. These patients were randomly selected and were divided into two groups: the placebo group (n = 22) and the intervention group (n = 21). The patients received either zinc sulphate (220 mg containing 50 mg zinc element) or a placebo for 12 weeks. Clinical examinations were obtained in terms of abnormal ocular movement, muscle power, and gait disorder. Results The results indicated that in the patients who received the zinc supplement, the mean score of depression was reduced compared to those in the placebo group, whereas the neurological examinations revealed that there were no differences between the treatment and control groups. Conclusion Therefore, the zinc supplementation is an appropriate choice for the depression management in patients with MS. © 2015 Published by Elsevier Urban & Partner Sp. z o.o. on behalf of Institute of Pharmacology.

Item Type: Article
Keywords: placebo; zinc sulfate; zinc sulfate, adult; Article; clinical article; controlled study; double blind procedure; eye movement disorder; female; gait disorder; hemiparesis; human; major depression; male; multiple sclerosis; muscle strength; neurologic examination; nystagmus; psychopharmacotherapy; randomized controlled trial; treatment duration; treatment outcome; decision making; Depressive Disorder, Major; disease management; multiple sclerosis; psychology; young adult, Adult; Choice Behavior; Depressive Disorder, Major; Disease Management; Double-Blind Method; Female; Humans; Male; Multiple Sclerosis; Young Adult; Zinc Sulfate
Page Range: pp. 606-609
Journal or Publication Title: Pharmacological Reports
Volume: 67
Number: 3
Publisher: Elsevier
Identification Number: 10.1016/j.pharep.2015.01.002
ISSN: 17341140
Depositing User: مهندس جمال محمودپور
URI: http://eprints.muk.ac.ir/id/eprint/802

Actions (login required)

View Item View Item